Free radical oxidation as an indicator of adaptation process and disintegration of cell structures: ethnic aspects

Abstract

Currently, the universality of the value of free radical reactions and the antioxidant defense activity in the organism adaptation to actions of different stressors have been proved. It has been found that dysadaptive disorders at the alien population of the North begin with a generalized membrane defect leading to metabolic disorders. However, the specific adaptation of the indigenous population originally living in the northern territories was formed in a series of many generations and it is anadaptive optimum for an adequate habitat. There is evidence that the property of the strong membrane stability to be less prone to lipid peroxidation processes and to be more resistant to destructive processes is typical for indigenous peoples of the North. The indigenous people living in the middle latitudes also show a higher resistance to various environmental factors. Important aspects of changes in lipid peroxidation of the Eastern Siberia small people representatives, Tofalars and Evenks, are the availability of adaptive responses in adolescence and development of dysregulation processes with age. Negative trends have been characteristic for the small indigenous ethnic groups in the past decade and, of course, they have affected the biochemical processes that provide its reactivity and adaptive capacity. Investigation of free radical oxidation reactions and the representatives of the small indigenous ethnic groups of the North and Siberia may provide additional information useful in the development of regional activities to prevent ethnospesific dysregulation states and, consequently, to overcome the depopulation process.