Mycotoxin Fumonisin B1 regulates the growth and death of the yeast Rhodotorula spp.

  • O. B. Ivanchenko St.-Petersburg State University of Refrigeration and Food Engineering, St.-Petersburg, Russian Federation
  • E. A. Martynova Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
Keywords: Rhodotorula spp., fumonisin B1, sphingosine, sphingomyelin, cell growth, cell surviving, apoptosis

Abstract

Aim of this work was to elucidate an influence of mycotoxin Fumonisin B1 [ 10–6 – 10–3 M] on the cultured yeast Rhodotorula spp. Fumonisin B1 has been found to regulate the yeast cell surviving, growth, number of budding cells, and apoptosis in the dose-dependent manner. Fumonisin B1 effects were strong dependent on the phase of yeast culture growth. One of the molecular mechanisms of Fumonisin B1 effects is an accumulation of sphingosine into yeast cells. Herein, we have shown that sphingosine inhibited the growth of Rhodotorula spp. In the dose-dependent manner. Sphingomyelin also has been found to inhibit yeast culture growth but less strong compared with sphingosine. In teraction between Fumonisin B1 and yeast Rhodotorula spp. may modu late the metabolic processes into microbiota

Published
2023-05-31
How to Cite
Ivanchenko, O. B., & Martynova, E. A. (2023). Mycotoxin Fumonisin B1 regulates the growth and death of the yeast Rhodotorula spp. Patogenez (Pathogenesis), 10(2), 75-82. Retrieved from https://pathogenesis.pro/index.php/pathogenesis/article/view/715
Issue
Vol. 10 No. 2 (2012): Патогенез
Section
Original investigations