Comperative study of the influence nonselective and high selective blokage of cholinoreactive structures on the development of the severe posthemorrage hypotention in rats with different individual resistence to circulatory hypoxia

Abstract

In experiments on rats using high frequency ultrasonic measurement technique and nonselective cholinolytic block agents (amizile, metacyne, cyclodole) and high seiective M-cholinoreceptor antagonists (pirensipine, 4-DAMP, tropicamide) it was shown, that in the development of severe posthemorrage hypotention in animals with high and low individual resistance to circulatory hypotension different subtypes of M-cholinoreceptors fulfil heterogeneous functions. M-1 cholinoreceptors are shock-limitation and M-4 cholinoreceptors shock-activating cholinoreactive structures. M-3 cholinoreceptors and H-cholinoreceptors do not influence on the dynamics of posthemorrage disorders of system and portal circulation, and lifespan alter the stop of bleeding. Low resistance of cardiovascuiar system to circuiatory hypoxia in the formation of shock process is scrutinized as disregulatory disease.