Моделирование алкогольной кардиомиопатии и современные аспекты ее патогенеза

S. V. Pirozhkov; M. N. Vukolova; V. V. Bulgakova; K. I. Valeeva; D. I. Peregud

doi:10.25557/2310-0435.2023.02.4-13

S. V. Pirozhkov I.M. Sechenov First Moscow State Medical University, Moscow , Russian Federation http://orcid.org/0000-0002-7116-3398
M. N. Vukolova I.M. Sechenov First Moscow State Medical University, Moscow , Russian Federation http://orcid.org/0000-0002-9046-169X
V. V. Bulgakova I.M. Sechenov First Moscow State Medical University, Moscow , Russian Federation http://orcid.org/0000-0002-4578-6874
K. I. Valeeva I.M. Sechenov First Moscow State Medical University, Moscow , Russian Federation http://orcid.org/0009-0001-1564-260X
D. I. Peregud National Center of Narcology – Branch of V.P Serbsky Research Centre for Psychiatry and Narcology, Moscow, Russian Federation http://orcid.org/0000-0002-2733-9640

DOI: https://doi.org/10.25557/2310-0435.2023.02.4-13

Keywords: alcoholic cardiomyopathy, modeling, pathogenesis, RAA system, cardiomyocytes apoptosis, alcohol-induced lipid peroxidation

Abstract

The review provides analysis of methods used to model alcoholic cardiomyopathy (ACM) in laboratory animals. It also considers the present time concepts of pathogenesis of the alcohol-induced myocardium deterioration. ACM development is determined by the dose of alcohol and duration of the intoxication period. Alcoholic injury of cardiomyocytes is initiated by various mechanisms and involves diverse signal pathways. The discussed mechanisms of ACM include changes in plasma membrane fluidity, initiation of apoptosis, free-radical lipid peroxidation, activation of the renin-angiotensin-aldosterone system, inflammatory reaction, as well as development of hypertrophy and fibrous transformation of the heart tissue.

Modeling of alcoholic cardiomyopathy and current aspects of its pathogenesis

Abstract