The allele of the rs5743810 polymorphism within the TLR6 gene is associated with a lower risk of polyvascular disease, myocardial infarction, and carbohydrate metabolism disorders in patients with coronary artery disease

Abstract

Background. We suggested that polymorphisms in Toll-like recep tor (TLR) genes are able to be associated with the clinical manifestations of atherosclerosis and carbohydrate metabolism disorders in patients with coronary artery disease. Aim. To investigate the association of polymorphisms in TLR genes with the clinical manifestations of atherosclerosis and carbohydrate metabolism disorders (i.e., type 2 diabetes mellitus and impaired glucose tolerance) in patients with coronary artery disease. Methods. We recruited 292 consecutive patients with coronary artery disease. Genotyping was carried out in 96-well plate format using the TaqMan SNP genotyping assay. We investigated eight polymorphisms in four genes: TLR1 (rs5743551 and rs5743611), TLR2 (rs3804099 and rs5743708), TLR4 (rs4986790 and rs4986791), and TLR6 (rs3775073 and rs5743810). Results. The A/A genotype of the rs5743810 polymorphism in TLR6 gene was associated with a lower risk of polyvascular disease (OR = 0.26, 95%CI = 0.10—0.71, p = 0.008; OR = 0.10, 95%CI = 0.02—0.41, p = 0.0012 in male patients and subjects at the age <55 years, respectively) and myocardial infarction (OR = 0.11, 95%CI = 0.03—0.42, p = 0.001). The allele of the same polymorphism was associated with decreased risk of polyvascular disease (OR = 0.55, 95% CI = 0.34—0.88, p = 0.013) regardless of age and gender. The A/G genotype was associated with a lower risk of atherosclerosis in subjects at the age <55 years (OR = 0.53, 95%CI = 0.29—0.97, p = 0.039) and risk of myocardial infarction in females (OR = 0.26, 95%CI = 0.07—0.94, p = 0.033). Conclusions. The allele of the rs5743810 polymorphism in TLR6 gene may protect against polyvascular disease, myocardial infarction, and carbohydrate metabolism disorders in patients with coronary artery disease.