Endothelial dysfunction in the pathogenesis of ischemic stroke: aspects of statin therapy

  • A. L. Khokhlov State budgetary educational authority "Yaroslavl State Medical University", Yaroslavl, Russia
  • A. Yu. Malygin State healthcare au thor ity of Yaroslavl Region "Clinical Hospital No.8", Yaroslavl, Russia
  • Yu. E. Melnikova State healthcare au thor ity of Yaroslavl Region "Clinical Hospital No.8", Yaroslavl, Russia
Keywords: ischemic stroke, endothelial dysfunction, cardiovascular events, HMG-CoA reductase inhibitors

Abstract

A 24-months study was conducted to assess efficacy of early and long-term statins administration in treatment of acute hemispheric ischemic stroke. During the first stage were analyzed parameters: lethality, incidence of recurrent cardiovascular events, grade of endothelial dysfunction and simvastatin safety. During the second stage, dynamic comparative analysis of study parameters depending on the drug (hydroxymethylglutaryl-coenzyme A reductase group) and treatment duration was performed.

Published
2017-12-02
How to Cite
Khokhlov, A. L., Malygin, A. Y., & Melnikova, Y. E. (2017). Endothelial dysfunction in the pathogenesis of ischemic stroke: aspects of statin therapy. Patogenez (Pathogenesis), 14(3), 58-64. Retrieved from https://pathogenesis.pro/index.php/pathogenesis/article/view/76
Issue
Vol. 14 No. 3 (2016): Pathogenesis
Section
Original investigations
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