Прогноз эффективности терапии у детей с перинатальными поражениями нервной системы

E. N. Kozhevnikova; N. P. Pyatkevich; S. V. Cherkasova; O. L. Chugunova; T. T. Batysheva; S. G. Morozov

E. N. Kozhevnikova Institute of General Pathology and Pathophysiology, Moscow, Russia
N. P. Pyatkevich Institute of General Pathology and Pathophysiology, Moscow, Russia
S. V. Cherkasova N.I. Pirogov Russian National Research Medical University, Russian Ministry of Health, Moscow, Russia
O. L. Chugunova N.I. Pirogov Russian National Research Medical University, Russian Ministry of Health, Moscow, Russia
T. T. Batysheva Scientific Practical Center of Pediatric Psychoneurology, Moscow Health Department, Moscow, Russia
S. G. Morozov Institute of General Pathology and Pathophysiology, Moscow, Russia https://orcid.org/0000-0001-5822-5729

Keywords: children, perinatal injury, leukocyte elastase, autoantibodies to proteins of nervous tissue, the technology of

Abstract

Evaluation of the effectiveness of treatment of 28 children under the age of 15.9 months with perinatal lesions of the nervous system and their effects depending on the activity of the destructive process in the brain tissue determined with the help of technology "Neuro-test", which includes the determination of the activity of serum leukocyte elastase, α1-proteinase inhibitor and levels of autoantibodies to proteins of neural tissue S100, OBM, GFAP and NGF. Assessment of the neurological status was performed using the international scale INFANIB (Infant Neurological International Battery, 1995). It is shown that the more pronounced were the changes in the indices of "Neuro-tests", the less effective was the ongoing therapeutic measures.

Forecast effective therapy in children with perinatal nervous system lesions

Abstract