Ultrasonic experimental model of epilepsy in Krushinsky-Molodkina rats strain

Abstract

Previously it was shown that the ultrasound frequency is 24.3 kHz, the power 116dB causes of nonlinear white rats epileptiform reaction. However, the rats random population of epileptic seizures in response to the ultrasound occur only in 6—13% of cases, which complicates the use of the method in practice. The purpose of the study: development of experimental model of the ultrasonic epileptiform reaction (UER) in Krushinsky—Molodkina (KM) rats strain and system of evaluation of anticonvulsants on them. Methods. Rats of KM strain was subjected to the action of ultrasound and the anticonvulsant sodium valproate was injected to rats intraperitoneally. The parameters of the UER was assessed by the duration of the latent period of motor excitation and convulsive seizure in seconds and severity of convulsive seizure in points. Results. In response to the action of ultrasound in rats of KM strain occurs UER in 99% of cases. On the model of UER confirmed the protective effect of sodium valproate. Conclusion. Ultrasonic experimental model of epilepsy in rats of KM strain can be used to study the mechanisms of pathogenic action of ultrasound on the central nervous system and the trials of anticonvulsants.