Markers of myocardial ischemia: pathophysiological substantiation of clinical application

Abstract

Prevalence of cardiovascular diseases with manifestations of ischemia dictates requirement for methods for early detection of ischemia, which provides more effective treatment, correction of patient’s condition, and prevention of possible complications. In modern clinical practice, a variety of methods is used for detection of IHD, which differ in their reliability and informativeness. One of promising methods for early diagnosis of coronary heart disease is identification of biochemical and molecular markers that are sensitive and specific for early ischemic damage of the myocardium in the absence of necrosis and increased markers of cardiomyocyte injury. The use of biomarkers for early diagnosis of ischemia is a promising approach to solving the complex problem of safe cardiomonitoring in patients with different cardiovascular diseases. By identifying rather simple but at the same time highly sensitive and specific markers for myocardial ischemia and cardioprotection, the efficiency of medical care can be significantly improved.