Blood corticosterone in rats with different susceptibility to audiogenic epilepsy

  • I. B. Fedotova M.V.Lomonosov Moscow State University, Moscow, Russia
  • A. V. Policarpova M.V.Lomonosov Moscow State University, Moscow, Russia
  • O. V. Perepelkina M.V. Lomonosov Moscow State University, Moscow, Russia http://orcid.org/0000-0001-9357-8407
  • G. M. Nikolaev M.V. Lomonosov Moscow State University, Moscow, Russia
  • O. V. Smirnova M.V. Lomonosov Moscow State University, Moscow, Russia
  • I. I. Poletaeva M.V. Lomonosov Moscow State University, Moscow, Russia http://orcid.org/0000-0002-1277-9918
DOI: https://doi.org/10.25557/2310-0435.2018.03.64-67
Keywords: audiogenic epilepsy, rat strains, corticosterone level, acoustic stress

Abstract

Aims. The Krushinsky-Molodkina (KM) rat strain, which was selected for a seizure response to a sound (audiogenic epilepsy, AE), is known as a model of human seizure states. Although the association of blood CS with stress reaction is an important practical issue, blood levels of corticosterone (CS) have never been analyzed in rats with AE in relation with seizures. Methods. Serum concentration of CS was measured using IBL International Corticosterone ELISA kits in KM rats, rats of the «0» strain, which was selected (based on F2 KM x Wistar hybrids) for the lack of seizures in response to a sound, and Wistar rats. Results. All KM rats developed AE seizures in response to a sound while no seizures were observed in rats of the «0» strain and Wistar rats. The increase in blood CS was observed only in KM rats at 30 min after AE seizure. At background, the level of CS was significantly higher in rats of the «0» strain, which did not develop seizures in response to a sound, than in KM and Wistar rats. CS levels remained unchanged in both «0» and Wistar rats after the sound exposure. Conclusions. The increase in blood CS occurred in KM rats at 30 min after the seizure episode. At background, the CS level was higher in rats of the «0» strain, which did not respond with seizures to a sound, than in Wistar and KM rats. Therefore, the blood level of CS depends in a complicated way on both AE and the selection history of the «0» rat strain.

Published
2018-12-27
How to Cite
Fedotova, I. B., Policarpova, A. V., Perepelkina, O. V., Nikolaev, G. M., Smirnova, O. V., & Poletaeva, I. I. (2018). Blood corticosterone in rats with different susceptibility to audiogenic epilepsy. Patogenez (Pathogenesis), 16(3), 64-67. https://doi.org/10.25557/2310-0435.2018.03.64-67
Issue
Vol. 16 No. 3 (2018): Pathogenesis
Section
Experimental researches