Measurement of the kinase mTOR expression in blood cell of patients with atopic dermatitis

  • I. V. Elistratova Institute of General Pathology and Pathophysiology, Moscow, Russia; Main Military Clinical Hospital of the National Guard of the Russian Federation, Balashikha, Russia
  • A. V. Grechko Federal Research Clinical Center for Resuscitation and Rehabilitation, Lytkino, Moscow region, Russia
  • E. A. Gorelova Timiryazevsky Branch of the Moscow Science and Practice Center for Dermatovenerology and Cosmetology, Moscow, Russia
  • S. V. Potapova Timiryazevsky Branch of the Moscow Science and Practice Center for Dermatovenerology and Cosmetology, Moscow, Russia
  • S. G. Morozov Institute of General Pathology and Pathophysiology, Moscow, Russia
DOI: https://doi.org/10.25557/2310-0435.2018.03.142-146
Keywords: atopic dermatitis, T cells, kinase mTOR, Raptor, Rictor

Abstract

The kinase mTOR expression was studied in blood cells of patients with atopic dermatitis (AD) using flow cytometry. The total level of lymphocyte mTOR protein was increased in AD patients compared with healthy donors. The mTOR protein expression in CD4+ and CD8+ T cells was higher in patients with AD in a relapse than in donors and patients in a remission. Both mTORC1 and mTORC2 complexes formed by mTOR kinase were found to participate in lymphocyte disruption during AD. Activation of Raptor and Rictor proteins (from mTORC1 and mTORC2, respectively) was significantly increased in lymphocytes of patients with mild and moderate AD (according to the SCORAD index).

Published
2018-12-31
How to Cite
Elistratova, I. V., Grechko, A. V., Gorelova, E. A., Potapova, S. V., & Morozov, S. G. (2018). Measurement of the kinase mTOR expression in blood cell of patients with atopic dermatitis. Patogenez (Pathogenesis), 16(3), 142-146. https://doi.org/10.25557/2310-0435.2018.03.142-146
Issue
Vol. 16 No. 3 (2018): Pathogenesis
Section
Brief reports