Катехоламины как медиаторы нейроиммунного взаимодействия при рассеянном склерозе

M. V. Melnikov; A. N. Boyko; M. V. Pashenkov; E. I. Gusev

M. V. Melnikov N.I.Pirogov Russian National Research Medical University, Moscow, Russia; National Research Center Institute of Immunology of the Federal Medical-Biological Agency of Russia, Moscow, Russia
A. N. Boyko N.I.Pirogov Russian National Research Medical University, Moscow, Russia
M. V. Pashenkov National Research Center Institute of Immunology of the Federal Medical-Biological Agency of Russia, Moscow, Russia
E. I. Gusev N.I.Pirogov Russian National Research Medical University, Moscow, Russia

Keywords: multiple sclerosis, catecholamines, Th17-cells, dendritic cells

Abstract

The neuroimmune interaction is one of fast developing directions in studying the pathogenesis of multiple sclerosis. The mechanism of this interaction is not sufficiently understood. The key role in regulation of this interaction is assumed to belong to neurotransmitters, among which catecholamines, specifically dopamine and norepinephrine, attract the greatest attention. Cells of both nervous and immune systems express dopaminergic and noradrenergic receptors. Dopamine and norepinephrine can influence the course of experimental autoimmune encephalomyelitis and multiple sclerosis by modulating functions of immune cells. This review presents literature and authors’ own data on the role of dopamine and norepinephrine in regulation of the nervous and immune system interaction in multiple sclerosis and focuses on possible mechanisms mediating the effect of dopamine and norepinephrine on the pathogenesis of multiple sclerosis, particularly the effect of dopamine and norepinephrine on the Th17 cell function and the dendritic cell-mediated Th17 immune response that plays a key role in the pathogenesis of multiple sclerosis.

Catecholamines as mediators of the neuroimmune interaction in multiple sclerosis

Abstract