The state of oxidative stress in patients with chronic heart failure when toxic encephalopathy

Abstract

Examined 18 patients with chronic circulatory insufficiency at toxic encephalopathy. The study was performed at admission (first day) and on the tenth day from the start of treatment. Oxidative stress was assessed by the level in the serum of the products of lipid peroxidation — diene conjugates (DC) and malondialdehyde (MDA). In the serum were determined as indicators of the endogenous antioxidant system: lipid antioxidant alpha-tocopherol (TF) and extracellular antioxidant enzyme ceruloplasmin (CP). An integrated assessment of oxidative stress was carried out using the calculation coefficient K. It is established that in patients with circulatory failure when toxic encephalopathy occurs strengthening of processes of lipid peroxidation in the serum of the blood increases the content of DC and MDA. However, the decrease of the level of TF and increasing the concentration of the CP was observed. Ongoing therapy to ten days contributed less pronounced deviations of the studied parameters. Integral assessment of oxidative stress did not reveal significant differences in the values of the K coefficient for the first and tenth day of the study, indicating the need for further development conducted a comprehensive therapy for the correction of circulatory failure, reducing symptoms of toxic encephalopathy with regard to the pathogenetic link of oxidative stress.