Multisystemic differential diagnosis of external respiration and cardiovascular synchronism in patients with different disease profiles

Abstract

The aim of this study was to assess the informative value of spiroarteriocardiorhythmographic indexes in dosed exercise tests to evaluate cardiorespiratory changes in patients with various diseases.
Methods. To implement the diagnostic algorithm was implemented using the Spiroarteriocardiorhythmograph-01 complex coupled with a bicycle ergometer. This approach allows induction of different respiration modes during unbiassed monitoring of cardiovascular synchronism indexes.
Results. Among the studied parameters, pulse pressure had the highest informative value. This index remained resistant to respiratory modes and at the same time, differs patients of all nosological groups from the control group. Moreover, in moderate exercise, pulse pressure differentiated a group of patients with the rheumatic profile. Cardiac stroke volume did not differ in groups with different profiles; however, the control group, this index increased with increasing exercise. Values of minute ventilation and double product were practically similar in the groups at rest and significantly increased with increasing exercise intensity in all groups. Values of cardiac output and volume of blood circulation during the one respiratory cycle practically did not differ during breathing at rest but changed in different ways during exercise in all groups. The coupling coefficient of cardiovascular and respiratory systems decreased as the exercise load increased to differentiate patients with different nosologies from the control group.
Conclusions. The proposed method can be used for individualized, non-invasive, rapid and automatic evaluation of the cardiovascular and pulmonary regulation in patients with various nosologies.