The role of NF-_B and ð38-mediated signaling pathways in hematopoiesis regulation under immobilization stress

  • A M Dygay FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • V V Zhdanov FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • L A Miroshnichenko FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • E V Udut FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • G N Zyuz`kov FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • T Y Khrichkova FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • E V Simanina FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • L A Stavrova FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • A V Chaikovskiy FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • V I Agafonov FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
Keywords: signaling pathways, transcriptional factor NF-kB, p38 mitogen-activated protein kinase, immobilization, granulocytic colony-stimulating factor

Abstract

Under the conditions of immobilization stress was found participation protein kinase p38 in the production of granulocyte colony-stimulating factor by hematopoietic microenvironment cells. The observed increased colony- forming ability in the absence of maturation processes elements of clonogenic granulocytic lineage bone marrow is implemented with the participation of NF-kB/IKK-dependent signaling and p38MAPK signaling pathway. It is shown important role of p38MAPK in the regulation of granulocytopoiesis, but not erythropoiesis.

Published
2015-11-30
How to Cite
Dygay, A. M., Zhdanov, V. V., Miroshnichenko, L. A., Udut, E. V., Zyuz`kovG. N., Khrichkova, T. Y., Simanina, E. V., Stavrova, L. A., Chaikovskiy, A. V., & Agafonov, V. I. (2015). The role of NF-_B and ð38-mediated signaling pathways in hematopoiesis regulation under immobilization stress. Patogenez (Pathogenesis), 13(3), 26-30. Retrieved from https://pathogenesis.pro/article/view/30
Issue
Vol. 13 No. 3 (2015): Pathogenesis
Section
Original investigations