The effect adrenoceptor agonists on product cytokines in development immune response

  • E Yu Sherstoboev FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • O G Shitikova FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • M G Danilets FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • N V Masnaya FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • E S Trofimova FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
  • A A Ligacheva FSBSI «Research Institute of Pharmacology and Regenerative Medicine named after E.D.Goldberg», 634028, Tomsk, Lenin Avenue, 3
Keywords: alpha- and beta-adrenoagonists, cytokines, humoral immune response

Abstract

The influence of alpha- and beta-adrenoceptor agonists on cytokine production by splenocytes of mice-hybrids F1 (CBAxC57Bl/6) in the development of humoral immune response was studied. It was shown that the use of phenylephrine inhibited of TNF-α and IL-1β production, while there was the increase of IL-2, IL-6, IL-10, and IFN-γ secretion after immunization. The isoproterenol administration in immunized mice resulted in the decrease of IL-2, IL-6 and IL-10 production in early terms after immunization, but it was observed the increase of TNF-α, IL-1β and IFN-γ production.

Published
2015-09-30
How to Cite
Sherstoboev, E. Y., Shitikova, O. G., Danilets, M. G., Masnaya, N. V., Trofimova, E. S., & Ligacheva, A. A. (2015). The effect adrenoceptor agonists on product cytokines in development immune response. Patogenez (Pathogenesis), 13(3), 45-49. Retrieved from https://pathogenesis.pro/article/view/33
Issue
Vol. 13 No. 3 (2015): Pathogenesis
Section
Original investigations