Lactoferrin beneficially influences the recovery of physiological and behavioral indexes in mice exposed to acute gamma-irradiation

DOI: https://doi.org/10.25557/2310-0435.2020.01.29-33
Keywords: human lactoferrin, acute gamma-irradiation, C57Вl/6 mice, survival rate, average life, open field test, research activity

Abstract

The aim of this study was to investigate effects of human lactoferrin (Lf) in mice exposed to acute gamma-irradiation at a sublethal dose.
Methods. C57Вl/6 2-2.5-month-old male mice were used for the experiments. Animals from experimental groups were exposed to whole-body gamma-radiation at a dose of 7.5 Gy. Some animals received an intraperitoneal injection of Lf (4 mg per animal) immediately and then at 24 hours after the irradiation. The effect of Lf on survival rate and life span was studied. The open field test was used to assess locomotor and research activity.
Results. The Lf administration increased the survival rate and life span of irradiated mice during the experiment. The dynamics of body weight normalized faster. In addition, Lf exerted a compensatory effect on the research activity of irradiated animals

Published
2020-03-05
How to Cite
Kopaeva, M. Y., Alchinova, I. B., Nesterenko, M. V., Cherepov, A. B., Zarayskaya, I. Y., & Karganov, M. Y. (2020). Lactoferrin beneficially influences the recovery of physiological and behavioral indexes in mice exposed to acute gamma-irradiation. Patogenez (Pathogenesis), 18(1), 29-33. https://doi.org/10.25557/2310-0435.2020.01.29-33
Issue
Vol. 18 No. 1 (2020): Pathogenesis
Section
Experimental researches