Activity of the humoral component in anti-endotoxin immunity in patients with influenza A

Abstract

Excessive entry into the blood of endotoxins of gram-negative microorganisms plays an important role in development of a number of diseases and their complications. Considering a possibility of enhanced bacterial translocation associated with influenza we focused on some indexes of humoral anti-endotoxic immunity in patients with moderate type A influenza.
The aim of the study was to perform a comparative analysis of changes in humoral antiendotoxic immunity during moderate influenza A.
Methods. The study was based on results of clinical observations and clinical and laboratory evaluation of 152 patients with moderate influenza A. The control group consisted of 15 healthy blood donors from the Simferopol Blood Transfusion Center. Anti-endotoxic antibodies of different classes were measured using the enzyme-linked immunosorbent assay.
Results. Concentrations of class G anti-endotoxin antibodies (AET AB IgG) were increased by 40-45%; all patients showed a tendency to gradual normalization of this index following the treatment. Noteworthy, the level of class M anti-endotoxic antibodies (AET AB IgM) was significantly increased by 3-3.5 times in the early period of the disease and therapy. This index generally normalized slower in patients with complicated disease; patients with the most severe complications had reduced levels of AET IgM antibodies compared to other groups.
Conclusion. In most cases, the enhanced bacterial translocation in influenza is primarily subcompensated, and studying indexes of anti-endotoxic immunity may be useful for predicting development of associated bacterial complications.