Importance of toxic metabolite mineralization in ensuring physiological aging and human longevity

Abstract

Background. Longevity with a high quality of life is one of the most important goals of global significance. Centenarians represent a biological elite of the human population, which encourages conducting in-depth studies of factors that provide physiological aging and longevity of people. One of these factors is the body’s ability to neutralize toxicity of metabolites through mineralization.
Aim. Тo identify biological characteristics of a long-liver’s body by the criterion of intoxication to endotoxin mineralization ratio as compared to patients of middle, elderly, and senile age.
Methods. Cuneiform dehydration of biological fluids was used as the main method. Auxiliary methods included determination of middle molecules in blood serum; determination of high-molecular fraction of circulating immune complexes in blood serum; and the x-ray spectral microanalysis of urine and oral fluid.
Results. The natural, age-related increase in the number of toxic metabolites in the human body significantly precedes the increase in toxin-neutralizing biomineralization activity. However, centenarians (patients older than 85) are an exception to this pattern: in this age group, the growth of biomineralization activity is adequate to the growth of endogenous intoxication. This provides a higher resistance of the body to toxic metabolites and determines a longer life expectancy.
Conclusion. The structure of facies of biological fluids allows integral evaluation of the current level of endogenous intoxication in relation to the biomineralization activity in the body. Long-livers were shown to have a higher ability to neutralize endotoxins through biomineralization, which provides them with a longer lifespan.