Developmental abnormalities in offspring of rats with experimental preeclampsia and their correction with fabomotizole
Abstract
Background. Preeclampsia is one of the leading factors of reproductive losses worldwide, which warrants searching for pharmacological treatments to restrict the maternal and neonatal mortality as well as offspring abnormalities. The study was aimed at the ability of fabomotizole to correct birth defects of offspring from rats with experimental preeclampsia.
Methods. Preeclampsia was modeled by replacing drinking tap water with 1.8 % NaCl from the first day of pregnancy. Fabomotizole at doses of 1 mg/kg and 10 mg/kg was administered orally daily throughout the pregnancy.
Results. Rats with experimental preeclampsia showed increased blood pressure, alterations of morphological and biochemical parameters of blood and urine, DNA damage in embryonic tissues, and disorders of antenatal and postnatal development. Administration of fabomotizole reduced the developmental abnormalities in rat offspring induced by experimental maternal preeclampsia.
