Комплекс биохимических нарушений на фоне дислипопротеидемии в эксперименте

S. A. Lepekhova; P. O. Inozemtsev; L. V. Korobeynikova; T. A. Gurepka; K. A. Apartsin

doi:10.25557/2310-0435.2022.02.55-58

S. A. Lepekhova Irkutsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences http://orcid.org/0000-0002-7961-4421
P. O. Inozemtsev Irkutsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences http://orcid.org/0000-0002-6623-0998
L. V. Korobeynikova Irkutsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences http://orcid.org/0000-0003-2642-121X
T. A. Gurepka Irkutsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences http://orcid.org/0000-0001-7982-3728
K. A. Apartsin Irkutsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences http://orcid.org/0000-0003-0577-9001

DOI: https://doi.org/10.25557/2310-0435.2022.02.55-58

Keywords: translational studies; dyslipoproteinemia; protein-synthetic function

Abstract

Translational studies on preventing the development of organ failure are relevant in the context of the COVID-19 pandemic as the number of patients developing cardiovascular diseases after COVID-19 has been growing.

Aim: To study the complex of biochemical disorders induced by an atherogenic diet in experiment and the timing of stable change development for the use in translational studies.

Materials and methods. The study was performed on Chinchilla rabbits aged at least 6 months with dyslipoproteinemia induced by an atherogenic diet. Serum concentrations of selected markers of biochemical disorders (total protein, albumin, triglycerides, total cholesterol, VLDL cholesterol, LDL, HDL) were measured during the study for up to 21 days.

Results: Already on the 4th day of experimental dyslipoproteinemia, serum indexes of lipid metabolism were increased and reached maximum values on the 21st day. At the same time, indexes of protein metabolism, on the contrary, were significantly reduced.

Conclusion: The complex of biochemical disorders identified in the study is consistent with the change’s characteristic of early manifestations of clinical atherosclerosis. This allows using the rabbit model of dyslipoproteinemia induced by the atherogenic diet for up to 21 days for evaluating early events in the complex of biochemical disorders in preclinical translational studies of new drugs and in the development of new technologies for early diagnosis, prevention and treatment of lipid metabolism disorders.

A complex of biochemical disorders associated with experimental dyslipoproteinemia

Abstract