Серотониновая нейропередача и ее регуляция через пальмитилирование: роль в нейропсихической патологии

T. V. Strekalova

T. V. Strekalova Institute of General Pathology and Pathophysiology, Moscow, Russian Federation; Research Institute of Space Medicine of All-Russian Center for Disaster Medicine “Protection” of the Federal Biomedical Agency of Russia, Moscow, Russian Federation; Institute of Physiologically Active Substances of the Russian Academy of Sciences, Chernogolovka of Moscow Region, Russian Federation

Keywords: Post-translational protein modification, depression, gene expression, animal model of human disorders, pharmacoresistance, individual susceptibility, serotoninergic neurotransmission

Abstract

Depression is a serious disorder with over a 12% prevalence in economically developed countries; more than 15% of the population experience a state of clinical depression at least once during a life span. At the same time, the efficacy of the therapy of depression remains to be lim ited. Obviously, better understanding of the bio logical basics of individual susceptibility to a depressive syndrome and resistance to its pharmacotherapy could substantially improve the prevention and the treatment of this pathology. Current review presents the analysis of some new data concerning the role of post-translational mechanisms of the regulation of the functions of serotoninergic neurotransmission in the pathogenesis of neuropsychiatric conditions, including depression. The analysis of these mechanism may result to the identification of new directions in the therapy of depressive disorder.

Serotoninergic neurotransmission and its regulation via palmitoylation: a role in the neuropsychiatric pathologies

Abstract