Mosaicism of mitochondrial mutations G15059A and G14846A of cytochrome B gene in atherosclerotic lesions of human aortic intima

Abstract

In most cases atherosclerosis of human great vessels is a morphological basis of mortality from cardiovascular pathologies. In the twenty-first century atherosclerosis has an epidemic character. Molecular genetic markers associated with atherosclerosis can help early diagnosis of this pathology. Studies of researchers all over the world are mainly devoted to autosomal mutations associated with atherosclerosis. Only a few studles are devoted to molecular genetic defects in the mitochondrial genome associated with atherosclerotic lesions. In this study we analyzed the association of the heteroplasmy level in mitochondrial mutation G15059A and G14846A of cytochrome B gene with atherosclerosis in individuals, the aortic intima of which was morphologically divided into segments with atherosclerotic lesions of varylng severlty.