Pathogenetic mechanisms of changes in activity of inflammation and fibrogenesis in patients with chronic diffuse liver disease after combined use perfluorocarbon emulsions and multipotent mesenchymal stromal cells

Abstract

The paper presents the results of the limited clinical study of chronic diffuse liver diseases (CDLD) treatment, that includes consecutive administration of perfluorocarbon emulsion and autologous bone marrow multipotent mesenchymal stromal cells (MMSC) into the liver blood flow. The results demonstrated the safety and clinical efficacy of this approach, which allows to reduce the activity of inflammation in the liver and improve its morphological structure and stop or slow the progression of fibrosis. The results obtained in 3D cell culture in vitro confirmed the pathogenetic mechanism of liver repair in patients with CDLD.