Inherent metabolic diseases and absorption (sodium dependent) of nutrients in the gut: is there a link between them

Abstract

Inherited metabolic diseases are classified into disorders of carbohydrate metabolism, amino acid metabolism, metabolism of organic acids and lysosomal storage diseases. In the last decade, dozens of new hereditary metabolic disorders, beyond these 4 categories are described. We compared the list of compounds, metabolism of which in inherited metabolic diseases is broken, with the list of nutrients which are transported through the mucosa of the small intestine by ion-dependent manner. Our analysis follows a definite conclusion. Metabolic disorders (and related diseases) and malabsorption, namely, violations of the ion-dependent (sodium-dependent) absorption of nutrients are linked. We can assume that the following principle is fulfilled: each violation of nutrient transport (eg, ion-dependent) through intestinal mucosa must meet its metabolic disease. Under this assumption, we can expect that soon descriptions of new metabolic diseases associated with metabolic disorders and bile absorption and short-chain fatty acids, flavonoids glucosides, hypoxanthine, etc. will be appeared.