The role of antibodies to GABA and glutamate in pathogenesis of neuropathic pain syndrome
Keywords:
antibodies to GABA, antibodies to glutamate, neuropathic pain syndrome, spontaneous pain paroxysms, allodynia
Abstract
The role of the antibodies to inhibitory neurotransmitter GABA and to excitatory neurotransmitter glutamate in pathogenesis of neuropathic pain syndrome on models of neuropathic pain syndrome was studied. It was shown that the development of experimental neuropathic pain syndrome is accompanied with induction of autoantibodies to glutamate and GABA. It was established that the antibodies to inhibitory neurotransmitter GABA have a pronociceptive effect and the antibodies to excitatory neurotransmitter glutamate have an antinociceptive effect.
Published
2023-05-27
How to Cite
Igon’kina, S. I., Grafova, V. N., Smirnova, V. S., Vetrile, L. A., Zaharova, I. A., Evseev, V. A., & Kukushkin, M. L. (2023). The role of antibodies to GABA and glutamate in pathogenesis of neuropathic pain syndrome. Patogenez (Pathogenesis), 10(4), 36-40. Retrieved from https://pathogenesis.pro/article/view/692
Section
Original investigations
