Pluronic block copolymers suppress LDL association

Abstract

It was previously shown that modified in any way low-density lipoprotein (LDL) form associates, and associates these properties exhibit atherogenic, causing accumulation of intracellular lipids. Was found a direct correlation between the size of LDL associates and their ability to cause accumulation of lipids in cells with native LDL did not form associates and did not possess atherogenic properties, i.e., did not cause the accumulation of intracellular lipids. You can assume that no association of LDL-C do not show their atherogenic properties. Based on this, particular interest is the search for modulators of the process of association of LDL. We hypothesized that this role could claim amphiphilic copolymers of propylene oxide and ethylene oxide, the so-called Pluronic. In this paper we studied the ability of Pluronic P85, L61 and F68 with different hydrophilic-lipophilic influence on the association of LDL. It is shown that Pluronic with strong hydrophobic properties (P85 and L61) at concentrations like or greater than the critical micelle concentration inhibited the process of association of LDL, whereas «hydrophilic» Pluronic F68 a t any concentration had no effect on the association of LDL.