The effect of polyethylene oxide on lipoidoz in experimental atherosclerosis in rabbits

Abstract

The paper presents the experimental research data on the effect of polyethylene oxide (PEO) with molecular weight of 1500 on the rabbit aorta with experimental atherosclerosis. When approaching the peak of the atherosclerosis model, a large internal surface area of the aorta has been shown to be injured by lipidosis foci, the dimensions of those (height and area) has been decreased in 6 month after the ceasing of in travenous injections of a 15% PEO solution, that is less pronounced in atherosclerosis spontaneous regression. The in vitro experiments revealed that 24 h incubation of aorta fragments with experimental atherosclerosis in PEO solution resulted in reduced height of lipidosis foci that was not observed during incubation in saline. Histological examination of aorta fragments after PEO injection as well as after incubation of aortic fragments with lipidosis foci in PEO solution revealed a reduced number of foam cells in the zone of atherosclerotic lesion. The mechanism of this phenomenon
should be more closely studied.