Predictors of reduced glomerular filtration rate

Abstract

Background. Cardiorenal relationships are one of the key problems in cardiology and nephrology. Decreased glomerular filtration rate is a symptom of renal pathology and cardiovascular diseases. Studying the causes of decreased glomerular filtration rate will provide further insight into pathological cardiorenal relationships.

Aim: To study the origin of decreased glomerular filtration rate.

Materials and methods: Data of a 6-year prospective follow-up of a natural group of 7,959 initially healthy men (workers of locomotive crews) aged 18 to 66 years were used to identify predictors of reduced glomerular filtration rate. For this purpose, a confusion matrix, a multivariate regression model, and a relative risk assessment were used.

Results: Decreased glomerular filtration rate was caused by arterial hypertension, hyperglycemia, aortic sclerosis, and creatininemia. All predictors determined with the mathematical models were statistically significant except for the predictor of arterial hypertension. The multivariate step-by-step analysis performed with the Statistica 6.0 software failed to include this factor into the list of predictors for the studied outcome. Therefore, the statistical properties of arterial hypertension and other predictors of decreased glomerular filtration rate had to be determined with other types of statistical analysis.

Conclusion: The statistical heterogeneity of arterial hypertension as a predictor might be related with and is probably due to its specific qualitative characteristics and the unique contribution of its detrimental effect to the formation and progression of impaired renal filtration capacity. The study showed a need for continuing the study of arterial hypertension and other predictors of reduced glomerular filtration rate using other types of statistical analysis in order to determine their unique, specific characteristics and their adverse role in the formation of this pathological symptom.