The role of inflammatory immunomodulators in the development of schizophrenia

Abstract

Schizophrenia is one of the most common multifactorial mental illnesses. Among the most important risk factors for the development of schizophrenia, such as genetic predisposition, epigenetic changes, stress, intrauterine, birth and postpartum complications, neuroinflammation and increased synthesis of pro-inflammatory cytokines play an important role. Also, one of the potential biomarkers for the development of schizophrenia is reelin, a glycoprotein involved in neurotransmission and synaptic plasticity. It should be noted that the pathogenetic mechanisms underlying schizophrenia have not yet been clearly established, however, the study of relationships between reelin gene expression, levels of pro-inflammatory cytokines, as well as positive and negative symptoms in patients with schizophrenia can be potentially informative for understanding the mechanisms of development of schizophrenia.