Определение регуляторного потенциала полиморфизмов, ассоциированных с преэклампсией

N. S. Karpova; O. P. Dmitrenko; M. K. Nurbekov

doi:10.25557/2310-0435.2023.03.50-53

N. S. Karpova Institute of General Pathology and Pathophysiology, Moscow, Russian Federation http://orcid.org/0000-0001-6391-4908
O. P. Dmitrenko Institute of General Pathology and Pathophysiology, Moscow, Russian Federation http://orcid.org/0000-0002-2067-0971
M. K. Nurbekov Institute of General Pathology and Pathophysiology, Moscow, Russian Federation http://orcid.org/0000-0002-9383-8026

DOI: https://doi.org/10.25557/2310-0435.2023.03.50-53

Keywords: polymorphisms, preeclampsia, pregnancy pathologies

Abstract

The aim of the study was to identify polymorphisms with the highest regulatory potential, which can become promising early predictors of preeclampsia.

Materials and methods. To select polymorphisms with the highest regulatory potential, bioinformatic databases were used: GWAS-catalog, dbSNP, RegulomDB, UCSC.

Results. We assessed the regulatory potential of 36 polymorphisms associated with preeclampsia and identified the 7 most promising polymorphisms for further study (rs1918975, rs1458038, rs10774624, rs7318880, rs1421085, rs259983 and rs4769612).

Determination of the regulatory potential of polymorphisms associated with preeclampsia

Abstract