Адаптация к периодической гипоксии защищает мозг при посттравматическом стрессовом расстройстве

E. B. Manukhina; V. E. Tseilikman; O. B. Tseilikman; H. F. Downey

doi:10.25557/10.25557/2310-0435.2023.04.4-12

E. B. Manukhina Institute of General Pathology and Pathophysiology, Moscow, Russian Federation; University of North Texas Health Science Center, USA http://orcid.org/0000-0002-8102-173X
V. E. Tseilikman South Ural State University (national research university), Chelyabinsk, Russian Federation; Novosibirsk State University, Novosibirsk, Russian Federation http://orcid.org/0000-0003-2935-7487
O. B. Tseilikman South Ural State University (national research university), Chelyabinsk, Russian Federation; Chelyabinsk State University, Chelyabinsk, Russian Federation
H. F. Downey University of North Texas Health Science Center, USA http://orcid.org/0000-0002-7280-1021

DOI: https://doi.org/10.25557/10.25557/2310-0435.2023.04.4-12

Keywords: post-traumatic stress disorder, biomarkers, adaptation to hypoxia, anxiety disorders, brain, adrenal glands, corticosteroids, liver

Abstract

Post-traumatic stress disorder (PTSD) develops after severe stress generally induced by life-threatening or traumatizing situations. PTSD frequently provokes serious psychic and smatic diseases. Although 50-60% of people have been exposed to traumatic events at least once during their lifetime most of them do not develop PTSD due to the activity of endogenous defense systems. These systems include antioxidants, prostaglandins, nitric oxide, heat shock proteins and others. The most known and studied method for enhancing the activity of endogenous defense systems is adaptation to intermittent normo- or hypobaric hypoxia (AH). This review focuses on the ability of AH to restrict detrimental effects of PTSD on the central nervous system and visceral organs and addresses possible mechanisms of the AH protection.

Adaptation to intermittent hypoxia protects the brain in post-traumatic stress disorder

Abstract