Adipose tissue in homeostasis

Abstract

Today, biology of adipose tissue cells, adipocytes, is the "forward line" of metabolomics and has a global social significance. Disordered fat metabolism is the most common pathology of modern mankind. For many years the predominant manifestation of this disorder has been excessive content of fat in the body, which is uncomfortable, movement-hampering, and complicated by many diseases. Over the years, this destructive trend has been growing. Fat is a critically important, evolutionarily adaptive source of energy for physical and intellectual activities. However, it become a major pathogenic factor of most common noninfectious diseases. The article discusses some mechanisms of this phenomenon and possible countermeasures. Hopefully, the high plasticity of adipose tissue (that has been found controllable) discovered by recent studies will contribute to success of this endeavor.