Микрочастицы тромбоцитов: образование и свойства

A. A. Kubatiev; T. G. Borovaya; V. G. Zhukhovitsky; S. G. Andreevskaya; N. V. Shevlyagina

A. A. Kubatiev "Research Institute of General Pathology and Pathophysiology", Moscow, Russia
T. G. Borovaya "Scientific Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamalei of the Ministry of Health of Russia", Moscow, Russia
V. G. Zhukhovitsky "Scientific Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamalei of the Ministry of Health of Russia", Moscow, Russia
S. G. Andreevskaya "Scientific Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamalei of the Ministry of Health of Russia", Moscow, Russia
N. V. Shevlyagina "Scientific Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamalei of the Ministry of Health of Russia", Moscow, Russia

Keywords: platelets, microparticles, remodeling, plasmalemma, angiogenesis, metastasis of tumors

Abstract

This article is a review that contains information about the formation and properties of microparticles of platelets, about their role in the physiological processes of the organism and pathogenesis of the disease. Are considered: mechanisms of remodeling plasmolemma and platelet cytoskeleton during formation of microparticles, the phenotypic features of microparticles and their role as molecular transmitters and activators of signaling pathways in target cells. Presents information on the involvement of microparticles in the pathogenesis of diseases associated with thrombus formation, in the regulation of angiogenesis and metastasis of tumors. Discusses the influence of platelet microparticles on inflammation factors and the potential role of microparticles in the pathogenesis of infectious diseases.

Platelet Microparticles: Formation and Properties

Abstract