Матриксные металлопротеиназы: структура, функции и генетический полиморфизм

A. S. Shadrina; I. V. Tereshkina; Ya. Z. Plieva; D. N. Kushlinsky; D. O. Utkin; A. A. Morozov; M. L. Filipenko; N. E. Kushlinsky

A. S. Shadrina Institute of Chemical Biology and Fundamental Medicine of the SB RAS, Novosibirsk State University, Novosibirsk, Russia
I. V. Tereshkina Moscow State Medical and Dental University. A.I. Evdokimova, Moscow, Russia
Ya. Z. Plieva Moscow State Medical and Dental University. A.I. Evdokimova, Moscow, Russia
D. N. Kushlinsky Russian Cancer Research Center. N.N. Blokhina of the Ministry of Health of Russia, Moscow, Russia
D. O. Utkin Moscow State Medical and Dental University. A.I. Evdokimova, Moscow, Russia
A. A. Morozov Moscow Regional Scientific Research Institute. M.F. Vladimirsky, Moscow, Russia
M. L. Filipenko Institute of Chemical Biology and Fundamental Medicine of the SB RAS, Novosibirsk State University, Novosibirsk, Russia
N. E. Kushlinsky Russian Cancer Research Center. N.N. Blokhina of the Ministry of Health of Russia, Moscow, Russia

Keywords: MMP, structure, functions, genetic polymorphism, various diseases

Abstract

Matrix metalloproteinases (MMPs) are enzymes of the hydrolase class that carry out enzymatic catalysis with
the help of a zinc ion bound in the active center. MMP functions are diverse, and a disturbance in the balance of their activity may be one of the etiological factors of various diseases. In this review, the classification of human MMP, the features of their structure and regulation, as well as the role in physiological and pathological processes in the human body are considered. A list of the most studied polymorphic versions of MMP genes has been given, their functional effects have been described, and the results of associative studies have been presented.

Matrix metalloproteinases: structure, functions and genetic polymorphism

Abstract