Antiproteinuric and nephroprotective activity of some peptide drugs in experimental nephropathy

Abstract

The aim of the study was to study the antiproteinuric and nephroprotective activity of some peptide drugs using the model of experimental Heymann active nephritis. Methods. Heymann’s active nephritis was modeled on rats by injecting an intraperitoneal antigenic suspension of the mother’s kidney in Freund’s complete adjuvant. To assess the effectiveness of the drugs, indicators of kidney function and immunity system were used. Results. The epithalamine was shown to be the most effective drug that increased the glomerular filtration rate and decreased the level of hematuria. Cortexin reduced proteinuria more than the other peptides. The most pronounced positive effect on the level of total protein in the blood was seen with thymodepressin. Epithalamin and cortexin reduced the level of total cholesterol. Epithalamin and timodepressin maximally decreased the level of urea. All the studied drugs equally led to the normalization of creatinine level and functional immunity, as well as in creased the level of cortisol reduced as the result of pathology. Epithalamin normalized the level of CD8+ T-cells and suppressed the production of cryoglobulins. Epithalamin was the most effective drug reducing endotoxicosis. Conclusion. The obtained results demonstrated that the use of peptide bioregulators in the treatment had positive effects on the functional activity of kidneys, the immune system and markers of endotoxicosis.