The role of proteolytic enzymes in the pathogenesis of atopic dermatitis

Abstract

The review provides data on the role of proteases of all five catalytic classes (serine proteases, cysteine proteases, threonine proteases, aspartate proteases, and metalloproteinases) in the pathogenesis of atopic dermatitis. We also discuss the protease activated receptors (PARs) and its role in the clinical manifestations of atopic dermatitis.