Хроническое системное воспаление в патогенезе метаболического синдрома, ассоциированного с гиперандрогенизмом (обзор литературы)

I. A. Igumnov; E. M. Sharifulin; L. V. Belenkaia; L. M. Lazareva; A. V. Atalyan; N. I. Vilson; L. V. Suturina

doi:10.25557/2310-0435.2020.03.12-18

I. A. Igumnov Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia http://orcid.org/0000-0002-1078-3657
E. M. Sharifulin Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia http://orcid.org/0000-0002-7245-9289
L. V. Belenkaia Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia http://orcid.org/0000-0003-4904-3709
L. M. Lazareva Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia http://orcid.org/0000-0002-7662-8529
A. V. Atalyan Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia http://orcid.org/0000-0002-3407-9365
N. I. Vilson Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia http://orcid.org/0000-0002-7604-6246
L. V. Suturina Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia http://orcid.org/0000-0002-6271-7803

DOI: https://doi.org/10.25557/2310-0435.2020.03.12-18

Keywords: chronic inflammation, obesity, metabolic syndrome, insulin resistance, hyperandrogenism, polycystic ovary syndrome

Abstract

This review addresses aspects of chronic systemic inflammation and its role in the pathogenesis of metabolic syndrome (MS)
associated with hyperandrogenism (HA).
The objective of this review was to systematize available data on the role of chronic systemic inflammation in the pathogenesis of metabolic complications of hyperandrogenism. Search for information was performed in the PubMed, EMBASE, Google Scholar, and E-library databases; 2000–2020 information was analyzed. The article presents the current view on chronic systemic inflammation and MS; major associations of MS and hyperandrogenism (HA) are also described. Polycystic ovary syndrome (PCOS), as well as MS, was shown to be associated with chronic systemic inflammation, insulin resistance, and obesity. However, it is not always possible to establish the causal nature of this relationship. The final part of the review summarizes information about the most significant markers of chronic systemic inflammation, which are specific for MS and HA.

Chronic systemic inflammation in pathways of metabolic syndrome associated with hyperandrogenism (review)

Abstract