Systemic inflammation and levels of lipopolysaccharide-binding protein and soluble cd14 receptors in a comorbidity of seasonal allergic rhinitis, essential hypertension. and obesity

Abstract

Background. The issue of multimorbid diseases that change their clinical phenotype, increase the risk of an unfavorable, mutually aggravating course, which requires special differentiated drug therapy, is an actual challenge for medicine.
Aim: to measure levels of lipopolysaccharide-binding protein and sCD14 in patients with a comorbidity of seasonal allergic rhinitis (SAR), essential hypertension, and obesity.
Materials and methods: 115 patients with moderate SAR were evaluated. All patients were divided into two clinical groups based on the presence of arterial hypertension. Patients were subdivided into subgroups according to the body mass index. The study was performed in two stages, 3-5 months before the pollination period (stage 1) and during the pollination period (stage 2). Concentrations of hs-C-reactive protein, lipopolysaccharide-binding protein, and sCD14 were measured.
Results: In patients with the comorbidity of SAR, essential arterial hypertension, and obesity, serum concentrations of lipopolysaccharide-binding protein and sCD14 were significantly higher during pollination of causal allergens than in patients of the comparison and control groups.

Conclusions: The study established a functional relationship between SAR exacerbation, systemic inflammation, and the proinflammatory
response of LPS-binding systems in patients with multimorbid pathology.