The role of TNFRSF7 and TNFRSF9 receptors in the development of systemic inflammation in patients with viral pneumonia

Abstract

Background. Systemic pro- and anti-inflammatory cascades of reactions are pathophysiological components of various critical states. It remains relevant to search for biological markers and pathogenetic mechanisms of effects on the macro-organism of receptor systems involved in innate and adaptive immunity induced by damage or infection.
Aim of the study. To evaluate the activity of the TNFRSF7 and TNFRSF9 receptor systems by determining their plasma concentrations in pneumonia patients with influenza A (H1N1).
Materials and methods. 85 patients with pneumonia associated with influenza A (H1N1) were examined. Among them, 30 patients had severe pneumonia, and 55 patients had non-severe pneumonia. Plasma levels of TNFRSF7 and TNFRSF9 were measured by flow cytometry.
Results. In patients with severe pneumonia and underlying influenza A (H1N1), the plasma concentrations of TNFRSF7 and TNFRSF9 receptors increased 1.8-fold and 2.3-fold, respectively.
Conclusion. The significant increase in plasma TNFRSF7 and TNFRSF9 receptors in patients with pneumonia associated with influenza A (H1N1) indicates the involvement of the TNF receptor superfamily in innate and adaptive immunity reactions and is related with severity of the disease.