Pathophysiological mechanisms of cerebral insufficiency in type 1 diabetes mellitus

Abstract

Type 1 diabetes mellitus (DM) starts at an early age, so its complications associated with impaired normal development of the child’s body impaired brain development and the formation of cerebral insufficiency (CI). Despite the high frequency of CI manifestations in clinical practice, the etiology and pathophysiological mechanisms of this type 1 DM complication remain insufficiently studied, and therefore their study is an important area of modern neurobiology and endocrinology. From the point of view of the pathogenesis of this disease, it is believed that dysglycemia (i.e., diabetes proper), as well as dysfunction of the nervous and vascular systems, play an important role in the development of cirrhosis in type 1 diabetes. This review considers some possible mechanisms of CI formation in type 1 DM.