Kisspeptin 10 reduces the manifestation of sexual dysfunction in rat models of acute psychogenic stress

Abstract

The aim of the study was to determine the biochemical indicators of hormone levels in the plasma of male rats after stress before and after the administration of kisspeptin 10.

Materials and Methods: Models of restrictive and vital stress were created for male rats of the Wistar line. The concentration of plasma hormones (luteinizing hormone, testosterone and corticosterone) was measured after different types of stress using the competitive ELISA.

Results: The administration of kisspeptin 10 increases the concentration of luteinizing hormone after different types of stress, both in intranasal and intraperitoneal administration, whereas the concentration of testosterone increases only in restrictive stress and systemic administration of the drug. The concentration of corticosterone significantly decreases in vital stress and systemic administration of the drug.

Conclusion: The results of the study suggest that kisspeptin-10 acts primarily centrally on brain structures involved in the realization of sexual function, independent of the regulation of sex steroids mechanism, and also has a stress-limiting effect in the model of psychological stress. The change in these indicators reduces the manifestation of sexual components of behavior in rats.